个人简介：
二级教授，博导，德籍华人科学家，回国前是德国Regensburg大学教授。2008年全职回国，任中科院武汉病毒所国家重点实验室PI。长期从事病毒学和再生医学基础与应用研究。2013年起担任湖工大中德生物医学中心主任。迄今已发表SCI学术论文173篇，出版专著2本，已培养博士、硕士30余名。国家科学技术奖励评审专家、科技部国际重大合作项目终审专家、教育部长江学者评审专家、湖北省相关人才入选者。
招生信息
1.招生学科：轻工技术与工程、生物工程、药学、化学工程与技术、生物与医药
2.研究方向：抗病毒药物与抗肿瘤药物
3.招生年度：2023年
科研项目
1. 新型全自动化三维仪样机定型（校企合作重大专项，2019-2024）
2. 一种促进抗衰因子有效吸收的制备方法（校企合作重大专项2019-2024）
成果获奖
2019中华预防医学会自然科学三等奖、江苏省“双创人才”
2020湖北省侨联梁亮胜科学技术奖
1.代表性论文(*通讯作者)
1. Xiong K., Jin R., Hu K. and Ding D. 1990 "Synthesis and cloning of the human growth hormone releasing factor gene"Chinese Journal of Biotechnology (English Version) 6, 243-250
2. Hu K. 2000 “Wechselwirkung beider Startstellen der Transkription von mutierten zirkulären Viroidmolekülen” Dissertation, Heinrich-Heine-Universität Düsseldorf, Germany 1-120 (in German)
3. Fels A., Hu K. and Riesner D. 2001 "Transcription of potato spindle tuber viroid by RNA polymerase II starts predominatly at two specific sites"Nucleic Acids Research 29(22), 4589-4597
4. Hu K., Beck J. and Nassal M. 2004 "SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcription"Nucleic Acids Research 32(14), 4377-4389
5. Hu K. et al. 2005 "Characterization of the human zinc finger protein 267 promoter: Essential role of nuclear factor Y" Biochimica et Biophysica Acta 1729, 14-23
6. Schnabl B., Hu K., Mühlbauer M. and Schoelmerich J. 2005 "Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10"Biochemical and Biophysical Research Communications 335, 87-96
7. Nadine K., Oliver B., Ashermann K., Hu K. and Riesner D. 2006 “Transcription of potato spindle tuber viroid by RNA polymerase II starts in the left terminal loop”Virology 347(2), 392-404
8.Hu K et al. 2007 “Chemically defined medium determines the differential potency of renal stem cells”Biotechnology Journal2(8), 992-995
3. Heber S., Denk L., Hu K.*. 2007 “Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium” Tissue Engineering13(2), 281-292
4. Minuth WW., Denk L. and Hu K.* 2007 “The role of polyester interstitium and aldosterone during structural development of renal tubules in serum-free medium”Biomaterials 28(30), 4418-4428
5. Minuth WW, Hu K * 2007 “Kontrolliertes Environment für Stammzellen – Generierung renaler Tubuli in chemisch definiertem Kulturmedium“Bioforum 4:28-29
6. Minuth WW, Denk L and Hu K.* 2007 “Kontrolliertes Environment für die Entwicklung von Stammzellen zu renalen Tubuli“Regenerativ Medizin 2(1):22-27
7. Minuth WW, Denk L, Hu K. et al. 2007 “The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor”Central European Journal of Biology 2(3), 307-325
8. Ke B. and Hu K *. 2007 "Environmental pollution and skin diseases" Medical Recapitulate 13(18), 1377-1379
9. Hu K* and Yao Y. 2008 “Advances in application of three-dimensional cell culture” Journal of Medical Molecular Biology 5(2):185-188
10. Feng H and Hu K*. 2008 "Aptamers against viral hepatitis from rational design to practical application" Virologica Sinica 23(5):315-320
11. Feng H and Hu K *. 2009 "Structural Characteristics and Molecular Mechanism of Hepatitis B Virus Reverse Transcriptase" Virologica Sinica 24(6):509-517
12. Hu K*. 2010 "From Minu3D cultural system to aldosterone-induced tubulogenesis" Journal of Clinical Rehabilitative Tissue Engineering Research 14(2):365-369
13. Chen P, Rayner S, and Hu K *. 2011 "Advances of bioinformatics tools applied in virus epitopes prediction" Virologica Sinica 26(1):1-7
14. Feng H, Beck J, Nassal M and Hu K *. 2011 “A SELEX-Screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replicationi“ Plos One 6(11):e27862
15. Zhao Z, Hong W, Zeng Z, Wu Y, Hu K et al. 2012 "Mucroporin-M1 inhibits hepatitis B virus replication by activating the MAPK pathawy and down-regulating HNF4α in vitro and in vivo" J Biol Chem.287(36):30181-90.
16. Wang W, Peng H, Li J, Zhao X, Zhao F, Hu K.* 2013 "Controllable inhibition of hepatitis B virus replication by a DR1-targeting short hairpin RNA (shRNA) expressed from a DOX-inducible lentiviral vector."Virus Genes 46(3):393-403.
17. Feng H, Chen P, Zhao F , Nassal M, Hu K* 2013 “Evidence for Multiple Distinct Interactions between Hepatitis B Virus P Protein and Its Cognate RNA Encapsidation Signal during Initiation of Reverse Transcription.Plos One 8:e72798.
18. Chen P, Yun G, Na H, Wei F, Li J, Zhao F, Rayner S*, Hu K. * 2013 "Computational evolutionary analysis of the overlapped surface (S) and polymerase (P) region in hepatitis B virus indicates the spacer domain in P is crucial for survival." PLoS One 8(4):e60098.
19. Pan X, Li XJ, Liu XJ, Tian XH, Hu KH.et al. 2013 Later Passage Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection.Journal of Virology87(20):10968-10979.
20. Tian X, Zhao F, Cheng Z, Zhou M, Zhi X, Li J, Hu K *. 2013 GCN5 acetyltransferase inhibits PGC1α-induced hepatitis B virus biosynthesis.Virologica Sinica28(4):216-22.
21. Zhou M, Zhao F, Li J, Cheng Z, Tian X, Huang Y, Zhi X and Hu K *. 2014 "Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with nonparenchymal cells" J Virol Methods 195:185-193
22. Zhou M, Huang Y, Cheng Z, Zhao F, Li J, Zhi X, Tian X, Sun W, Hu K * 2014 Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes.J Virol Methods207:29-37
23. Tian Xiaohui, Zhao Fei, Sun Weihua, Zhi Xiaoguang, Hu Kanghong * 2014 CRTC2 enhances HBV transcription and replication by inducing PGC1alpha expression.Virology Journal 11:30, doi: 10.1186/1743-422X-11-30.
24. Cheng Z, Sun G, Guo W, Huang Y, Sun W, Zhao F, Hu K* 2015 Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines.Virologica Sinica 30(4):261-268.
25. Cheng ZK, Zhi XG, Sun G, Guo W, Zhao F, Hu KH * 2016 Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines.Journal of Medical Virology 88(4):653-663
26. Danzhen Pan , Yong Lin, Weimin Wu, Jingjiao Song, Ejuan Zhang, Chunchen Wu, Xinwen Chen, Kanghong Hu et al.2015 “Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model”PLoS One 10(5):e0125658
27. Peng Ke, Honghao Sun, Mingxing Liu, Zhengding Su, Kanghong Hu et al. 2016 “Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide”IET Nanobiotechnol., 10(1): 8-12
28. Xiaoli Ye, Ming Zhou, Yonggang He, Yanmin Wan, Weiya Bai, Shuai Tao, Yanqin Ren, Xinxin Zhang, Jianqing Xu, Jing Liu, Junqi Zhang, Kanghong Hu* et al. 2016 “Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide”Scientific Reports 6:29391DOI: 10.1038/srep29391
29. 孙维华朱祥尧晨光孙鸽寇铮*胡康洪* 2016“伴HBV感染性肝癌调控枢纽基因筛选与初步鉴定”生物信息学 14（4）：203-212
30. 刘求明尧晨光郭晓红胡康洪*2016“抗乙肝病毒药物研究新进展”病毒学报 32（5）：649-657
31. HU Kanghong et al. 2017 “KNK437 Inhibits Replication and Transcription of the Hepatitis B Virus”Chinese Journal of Virology (English Version) 01:24-35
32. Mengying Ji and Kanghong Hu* 2017 "Recent advances in the study of hepatitis B virus covalently closed circular DNA"Virologica Sinica32(6):454-464
33. Yao Chengguang, Xi Caili, Hu Kanghong et al. 2018 "Inhibition of enterovirus 71 replication and viral 3C protease by quercetin" Virology Journal 15(1):116. doi: 10.1186/s12985-018-1023-6.
34. Min Chen, Ni Li, Nan Wang, Hu Kanghong et al. 2018 "Synthesis, structure and antitumor studies of a novel decavanadate complex with a wavelike two-dimensional network" Polyhedron155:313-319.
35. Yao Chengguang#, Hu Kanghong # et al. 2019 "Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene"Genes & Genomics41(3):343-357. doi: 10.1007/s13258-018-0760-7
36. Xiaokang Hu, Huan Wang, Bo Huang, Ni Li, Kanghong Hu* et al. 2019 "A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities" Journal of Inorganic Biochemistry193:130-132
37. Wei Yanhong, Wang Haijie, Xi Caili, Li Ni, Li Dong, Yao Chengguang, Sun Ge, Ge Hongmei, Hu Kanghong* and Zhang Qian* 2020 “Antiviral effects of novel 2-benzoxyl-phenylpyridine derivatives”Molecules 25,1409;doi:10.3390/molecules25061409
38. Rominah OD, Hu M, Wei Y, Hu KH* 2020 “Recent advances of enterovirus 71 3Cpro targeting inhibitors” Virology Journal 17:173 doi.org/10.1186/s12985-020-01430-x
39. Huang B, Ke D, Xiong Z, Wang Y, Hu K et al. 2020 “Covalent hybrid materials between polyoxometalates and organic molecules for enhanced electrochemical properties” J Mater Sci Energy materials doi.org/10.1007/s10853-020-04404-0
40. 张珊陈忠伟孟诗敏丁庆林钟自彪魏艳红叶启发胡康洪*2020“真核起始因子3e亚基与原发性肝癌的发生与发展正相关”世界华人消化杂志28（12）:475-485
41. Zhen WT, Li HL, Hu KH et al. 2021 “Chondromalacia patellae:current option and emerging cell therapies” Stem Cell Research & Therapy 12:412 doi.org/10.1186/s13287-021-02478-4
42. Zhang RJ, Bao J, Qiao JL, Li WS, Feng Q, Hu KH * and Sun BL* 2021 “Long-term efavirenz exposure induced neuroinflammation and cognitive deficits in C57BL/6 mice” Biochemical and Biophysical Research Communication584:46-52
43. Chen Z, Wang Y, Wang X, Xiao Z, Wu P*,Hu K* 2022 “Rational design and synthesis of organic-inorganic hexavanadate hybrids with p-halogenated benzoyl ligands” Journal of Molecular Structure 131451
44. Wang LS*, Guo C, Hu D, Zhao YX, Liu HH, Dong YJ, Sun SB, Liu X, Hu KH & Wei YH* 2022“Syntheses, characterization andinhibition activities against coxsackievirus B3 of lodobenzoic hydrazide functionalized hexamolybdates” Frontiers in Chemistrydoi:10.3389/fchem.2022.841151
专著
1. 胡康洪合著《中国学科发展战略再生医学》2017 ISBN 978-7-03-043400-5科学出版社
2. Minuth WW, Strehl R & Hu KH《3D Kulturen-Zellen, Kultursysteme und Environment》2006 ISBN 978-3-89967-316-2 Pabst Science Publishers
代表性专利
1.胡康洪等“一种抗HBV诱饵适体及其筛选方法”发明专利授权号：ZL201110410737.7
2.胡康洪等“利用慢病毒载体介导RNAi的方法”发明专利授权号：ZL 201110110644.2
3.胡康洪等“人原代肝细胞与肝非实质细胞共培养方法”发明专利授权号：ZL 201310282851.5
4.胡康洪“三维灌流式细胞培养器及其应用”发明专利授权号：ZL 201410024728.8
5.胡康洪“N-甲酰基-3,4-亚甲二氧基苄基-γ-丁内酯在制备抗乙型肝炎病毒药物中的应用”发明专利授权号：ZL 201610407438.0
6.胡康洪“一种批量简易移液枪头装盒装置”发明专利授权号：ZL 201510596259.1
7.胡康洪等 “一种与原发性肝细胞癌发生发展密切相关的特异性标志物及其应用”发明专利授权号：ZL201910851143.6
8.魏艳红、胡康洪等“酯类化合物在制备抗柯萨奇病毒B3型的药物中的应用”发明专利授权号：ZL 201611192757.0
9.魏艳红、胡康洪等“芳香酯类化合物在制备抗肠道病毒71型药物中的应用”发明专利授权号：ZL 201611192748.1
10.胡康洪“一种三维灌流式细胞分离器”实用新型专利授权号：ZL 201420033628.7
11.胡康洪等 “一种具有实时检测和监测功能的细胞培养箱” 实用新型专利授权号：ZL 202020994548.3
12.胡康洪等 “一种可自动加样的细胞培养装置” 实用新型专利授权号：ZL 202021375799.X
13.胡康洪等 “一种细胞培养液存储瓶” 实用新型专利授权号：ZL 202021375816.X
14.胡康洪等“一种防水雾型细胞培养箱”实用新型专利授权号：ZL 202021376535.6
15.胡康洪等“一种酶标板清洗器”实用新型专利授权号：ZL 201620514335.X
16.胡康洪等“一种用于深层挫裂伤的免缝合式医用拉链”实用新型专利授权号：ZL 201420699686.3
17.胡康洪等“一种复合维生素营养霜及其脂质体包覆物的制备方法”发明专利公开号：ZL 201710201247.3
18.胡康洪等 “甲基莲心碱在制备抗乙型肝炎病毒药物中的应用” 发明专利公开号：ZL 202210531337.X
19.胡康洪等“一种对HBV易感的人胎肝细胞分离、冻存与复苏方法及应用”发明专利公开号：ZL 201410009255.4
20.胡康洪等“亚硒酸钠在制备治疗或预防乙型肝炎病毒感染药物中的应用”发明专利公开号：ZL 201410009255.4
21.胡康洪等“一种包覆磷脂酶的多囊脂质体及其制备方法和应用”发明专利公开号：ZL 201910608903.0
22.胡康洪等“一种抗衰老组合物及其制备方法”发明专利公开号：ZL 202011162104.4
23.胡康洪等“Anderson构型的钼钒杂多酸衍生物及其制备方法和应用”发明专利公开号：ZL 202210318040.5”
24.胡康洪等“一种多模式三维灌流式细胞培养仪”发明专利公开号：ZL 201910989223.8
25.胡康洪 “一种三维灌流式细胞培养仪”发明专利公开号：ZL 201911035634.X
26.胡康洪 “一种三维灌流式细胞培养仪中的培养液容器存储装置”发明专利公开号：ZL 201911035492.7
27.胡康洪 “一种三维灌流式细胞培养仪中的培养仓通风循环系统”发明专利公开号：ZL 201911035635.4
28.胡康洪 “一种三维细胞培养仪中的培养仓结构”发明专利公开号：ZL 201911035473.4
